Ulster Head Coach, Mark Anscombe, has made four changes in total. Captain Johann Muller returns, while Declan Fitzpatrick is selected at tighthead having recovered from the injury that he picked up against Connacht in Galway.
In the only other change, Nick Williams, who signed a new two-year deal with the Province this week, starts at Number 8, with Roger Wilson moving to the bench.
Ireland international centre, Stuart Olding is selected among the substitutes and is in line to make his first appearance of the season if he is called upon.
Ulster beat the Ospreys at the Liberty stadium last year, but the Welsh region have won their last 10 home games and are one of two unbeaten sides in the RaboDirect PRO12 this season.
The game will be shown live on BBC Two Northern Ireland.
Ulster XV and replacements to face Ospreys, RaboDirect PRO12, Liberty Stadium, Friday 4th October (kick off 19:05);
(15-9): C Gilroy, A Trimble, J Payne, L Marshall, M Allen, P Jackson, P Marshall;
(1-8): T Court, R Best, D Fitzpatrick J Muller (Captain), D Tuohy, R Diack, C Henry, N Williams; Replacements
(16-23): R Herring, C Black, B Ross, I Henderson, R Wilson, M Heaney, S Olding, D Cave.
Referee: Peter Fitzgibbon (IRFU, 49th competition game)
Assistant Referees: Jon Mason, Wayne Davies (both WRU)
Citing Commissioner: Dennis Jones (WRU)
TMO: Derek Bevan (WRU)
