Edinburgh's two defeats in their last eight matches in all tournaments have both been in away games, against Glasgow Warriors over Christmas and in Lyon on 17th January.
The Scotsmen are unbeaten at home to Welsh teams this season, having drawn with Scarlets and beaten the Dragons and Blues at BT Murrayfield.
Ospreys have lost just one of their last four encounters in the Guinness PRO12: 10-22 at Scarlets in round 12.
The Welshmen have lost their last three away games in the competition but have not lost four in a row on the road since season 2007/08.
Ospreys' only victory in their last nine visits to Scotland since 2009 was 15-14 over Edinburgh at BT Murrayfield in February 2012.
Edinburgh have won just one of their last four fixtures against Ospreys: 31-25 at Meggetland on 28 February 2014.
At Myreside, 8.05pm. Live on BBC ALBA
Referee: Gary Conway (IRFU, 7th competition game)
Assistant Referees: Graeme Wells, Stephen Hart (both SRU)
Citing Commissioner: John Kirk (SRU)
TMO: Iain Ramage (SRU)
Edinburgh Rugby
24 - 16
HT: 10 - 9
Ospreys
13th February 2015
20:05
Myreside
2891
Guinness PRO12