Zebre are attempting to achieve a 'grand slam' of home victories over the four Welsh regions, having beaten Blues and Ospreys in 2014 and Dragons in 2015.
Scarlets top the Guinness PRO12 table for the first time since round 4 of the 2012/13 campaign, having won their last six fixtures to equal their best ever run in the competition.
The Welshmen have not been defeated in Italy since Treviso did so in September 2012.
At Stadio Sergio Lanfranchi, 2pm local time (1pm UK & Ireland). Live on S4C/RAI Sport
Referee: Dudley Phillips (IRFU, 51st competition game)
Assistant Referees: Matteo Liperini, Filippo Bertelli (both FIR)
Citing Commissioner: Marco Cordelli (FIR)
TMO: Alan Falzone (FIR)
Zebre Rugby
8 - 20
HT: 8 - 6
Scarlets
4th October 2015
14:00
Stadio Sergio Lanfranchi
2000
GUINNESS PRO12
Referee: Dudley Phillips