Connacht have not lost successive matches in Galway since the end of the 2014/15 season.
Ospreys have lost just one of their last five Guinness PRO12 fixtures: 26-46 at home to Ulster in round 22 last season.
During the last campaign Ospreys won just one of their eight encounters with Irish provinces: 21-17 against Munster in Cork.
Connacht achieved the season's double over Ospreys last year for the first time since 2003/04.
Ospreys overall record at the Sportsground is won eight, lost five.
Overall Guinness PRO12 head to head record:
Played 26, Connacht won 8, Ospreys won 18.
At Sportsground, 7.35pm. Live on TG4/S4C
Referee: Ben Whitehouse (WRU, 26th competition game)
Assistant Referees: Claudio Blessano (FIR), Leo Colgan (IRFU)
Citing Commissioner: Tim Lowry (IRFU)
TMO: Alan Falzone (FIR)
Read more at http://www.pro12rugby.com/preview/preview-connacht-rugby-v-ospreys-rugby/#ylWbEKRhVx3b6vqf.99
Connacht Rugby
11 - 32
HT: 3 - 10
Ospreys
10th September 2016
19:35
The Sportsground
5749
GUINNESS PRO12