In the pack Jack McGrath is once again selected at loosehead prop after his try scoring performance last weekend with Marty Moore coming in from the start this weekend. Richardt Strauss also starts at hooker tomorrow evening.
In the second row Devin Toner is joined by former Connacht player Mike McCarthy who played 160 times in two spells out west.
It's a completely new back row with captain Rhys Ruddock leading the charge from blid side flanker and Josh van der Flier selected at open side. Finally Jordi Murphy starts from number eight.
In the backs Rob Kearney starts at full back in only his second Guinness PRO12 game of the season on his 170th appearance for Leinster. Fergus McFadden is once again selected on the right wing with Dave Kearney coming in on the left having been an unused substitute in the win over Munster last Sunday.
Ben Te'o returns from injury and takes over the inside centre jersey from Luke Fitzgerald with Garry Ringrose outside him at 13.
Luke McGrath and Johnny Sexton both return from injury to start in the half backs.
Sean O'Brien will start from the bench for what will be his 100th cap for Leinster should he come on. He made his debut in September 2008 against the Cardiff Blues and has gone on to represent his country 41 times.
Finally, Leinster Rugby would like to advise those attending the game that with other events such as Funderland on at the RDS during the busy festive period, parking will be extremely limited and supporters are asked to consider public transport and car pooling as a means of attending the game.
LEINSTER:
15. Rob Kearney
14. Fergus McFadden
13. Garry Ringrose
12. Ben Te'o
11. Dave Kearney
10. Johnny Sexton
9. Luke McGrath
1. Jack McGrath
2. Richardt Strauss
3. Marty Moore
4. Devin Toner
5. Mike McCarthy
6. Rhys Ruddock CAPTAIN
7. Josh van der Flier
8. Jordi Murphy
16. James Tracy
17. Peter Dooley
18. Michael Bent
19. Ross Molony
20. Sean O'Brien
21. Eoin Reddan
22. Ian Madigan
23. Zane Kirchner
Referee: George Clancy (IRFU, 75th competition game)
Assistant Referees: Leo Colgan, Mark Patton (both IRFU)
Citing Commissioner: Peter Ferguson (IRFU)
TMO: Marshall Kilgore (IRFU)