There are eight changes in total from the XV that accounted for the Ospreys last time out with a welcome return from injury for Ireland international Dave Kearney while Academy back Joey Carbery is in line to make his debut from the bench.
Zane Kirchner starts at full back for his 12th start of the season, with Isa Nacewa captaining the side from the right wing and Dave Kearney coming onto the left for his first game since injuring his shoulder in the Six Nations game against France.
In the centre, Cullen has again gone with Ben Te'o and Garry Ringrose, while in the half backs Luke McGrath and Cathal Marsh will start at nine and ten respectively.
In the pack it's a new front row combination with Peter Dooley, James Tracy and Tadhg Furlong packing down. While in the second row Mick Kearney and Hayden Triggs start together for only the second time this season.
In the pack Dominic Ryan starts having won his 100th Leinster cap last time out against the Ospreys with try scorer from that same game, Dan Leavy, and Jordi Murphy completing the pack.
Amongst the substitutes UCD flyhalf Joey Carbery is in line to make his first appearance for the senior team having played for the Leinster A team last weekend against London Welsh scoring 14 points with the boot.
Leinster Rugby have also announced this afternoon that 35,000 tickets have now been sold for the April 2nd game against Munster in the Aviva Stadium. With the race for top two and indeed play-off places getting closer every round, the Round 19 Guinness PRO12 game between the two provinces is expected to play a huge role in deciding the final positioning.
Tickets for the game are still available at: leinsterrugby.ie/tickets
LEINSTER (Leinster caps in brackets):
15. Zane Kirchner (60)
14. Isa Nacewa (143) CAPTAIN
13. Garry Ringrose (15)
12. Ben Te'o (32)
11. Dave Kearney (96)
10. Cathal Marsh (11)
9. Luke McGrath (42)
1. Peter Dooley (16)
2. James Tracy (15)
3. Tadhg Furlong (43)
4. Mick Kearney (3)
5. Hayden Triggs (9)
6. Dominic Ryan (100)
7. Dan Leavy (12)
8. Jordi Murphy (73)
16. Bryan Byrne (12)
17. Jeremy Loughman (2)
18. Michael Bent (62)
19. Ross Molony (16)
20. Peadar Timmins (2)
21. Isaac Boss (132)
22. Joey Carbery (0)
23. Noel Reid (56)
Referee: George Clancy (IRFU, 78th competition game)
Assistant Referees: Lloyd Linton, Mike Adamson (both SRU)
Citing Commissioner: Douglas Hunter (SRU)
TMO: Jim Yuille (SRU)
Guinness PRO12 Leinster News
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