Luke Fitzgerald, who pulled up with an injury in the first half of Leinster's game against Connacht three weeks ago, starts on the left wing, with Fergus McFadden completing the back three.
Ben Te'o and Noel Reid will start the game as Leinster's midfield pairing, with Luke McGrath and Ian Madigan selected as the provinces starting half-back partnership.
There is a new-look front row for Friday's game with Cian Healy, Richardt Strauss and Mike Ross in for Jack McGrath, Sean Cronin and Tadhg Furlong, who all started in the win over Munster.
Leinster Academy lock Ross Molony starts in the second row with Mick Kearney, who will make his fifth appearance for the province.
Rhys Ruddock captains Leinster from the back row alongside Josh van der Flier, who will make his twelfth start of the season, and Jordi Murphy, who starts at number 8.
A win over Scotland's capital club could keep Leinster at the top of the GUINNESS PRO12 table with just two rounds of regular season games to go after this weekend's fixtures.
Leinster
15. Rob Kearney (172 Leinster caps)
14. Fergus McFadden (141)
13. Ben Te'o (35)
12. Noel Reid (57)
11. Luke Fitzgerald (150)
10. Ian Madigan (143)
9. Luke McGrath (45)
1. Cian Healy (152)
2. Richardt Strauss (126)
3. Mike Ross (130)
4. Ross Molony (19)
5. Mick Kearney (4)
6. Rhys Ruddock (108) CAPTAIN
7. Josh van der Flier (22)
8. Jordi Murphy (75)
Replacements
16. Sean Cronin (109)
17. Peter Dooley (17)
18. Tadhg Furlong (46)
19. Devin Toner (178)
20. Dominic Ryan (102)
21. Eoin Reddan (135)
22. Cathal Marsh (12)
23. Dave Kearney (98)
Guinness PRO12 Leinster News
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