Meanwhile, Ulster recorded a fifth consecutive victory last time out as they beat Zebre 13-6 at home.
And the omens don't look good for Leinster as Ulster have lost just once away from home since September and have won on their last three regular season visits to a fellow Irish province.
Indeed Ulster won both regular season encounters last campaign but after Leinster enacted revenge in the RaboDirect PRO12 Final, Jackson is all too aware of the danger they possess.
"They will always be tough," Jackson said. "I just try and focus on what I can do.
"There is not much else you can do other than that and the only thing you can have any effect on is your own game and your own team's game and that is what I'll be looking to do.
"I doubt Leinster have lost three games in a row, especially in the last while.
"They don't want to lose again and we certainly want to get the win there so both teams will be really fighting for it."
Ulster head coach Mark Anscombe has made nine personnel changes and three positional switches to the team that beat Zebre at Ravenhill last weekend.
Six of the seven starting backs are Ireland internationals, with Paul Marshall partnering Jackson in the half backs, Luke Marshall and Darren Cave starting in midfield and Andrew Trimble and Craig Gilroy selected on the wings.
Ricky Andrew, who played against Zebre at Ravenhill, keeps his place at full-back.
Callum Black makes his 50th appearance for the province and starts at loosehead, with Rob Herring coming in at hooker and Declan Fitzpatrick selected at tighthead.
Lewis Stevenson wears the No.4 jersey, with Dan Tuohy returning to the second row alongside him.
Robbie Diack is named as captain for the game and moves to blindside, with Sean Doyle continuing at openside and Roger Wilson, who has recovered from injury, coming back in at No.8.
Tom Court, Ruan Pienaar and Jared Payne are named as substitutes alongside Niall Annett, Ricky Lutton, Neil McComb, Mike McComish and Michael Allen.
As for Leinster, coach Matt O'Connor has retained nine of last week's starting XV.
Back in from their pre-Christmas training camp with the Irish squad come Dave Kearney, Mike McCarthy and Sean O'Brien, while Jimmy Gopperth replaces Ian Madigan at fly-half.
Brendan Macken is promoted from the bench to take his place in the centre beside Noel Reid, who retains his place at 12, while Rhys Ruddock replaces Kevin McLaughlin.
Zane Kirchner continues at full-back, with Luke Fitzgerald and Isaac Boss also retained at 11 and nine respectively.
There are no changes in the front row with Michael Bent, Aaron Dundon and Martin Moore once again selected.
Jordi Murphy is again named at No.8 with Ruddock and O'Brien completing the back row. O'Brien makes a welcome return from injury and comes in for only his second RaboDirect PRO12 appearance of the season.
Leo Cullen captains the side from the second row and O'Connor admitted the veteran would make a great coach should he choose to go down that route.
O'Connor said: "He's certainly a leader of men, he's got vast experience and rugby knowledge and I would imagine that he would be a very good head coach, it just depends how the thing twists and turns and how long he wants to be in the game.
"Leo's been an unbelievable leader for the organisation on and off the field. He's got all that knowledge, he understands what's required at the very top level and I'm really looking forward to working with him."
At RDS Dublin, 6.45pm.
Referee: John Lacey (IRFU, 32nd competition game)
Assistant Referees: Peter Fitzgibbon, Eddie Hagan-O'Connell (both IRFU)
Citing Commissioner: Eugene Ryan (IRFU)
TMO: Sean Flannery (IRFU)
LIVE on RTE and BBC NI
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