The Welshmen's only victory over a Scottish opponent since February 2014 came when Edinburgh visited Rodney Parade in May 2015.
Glasgow Warriors have slipped to successive Guinness PRO12 defeats, against Blues and Ulster, but have not lost three in a row in the same season in the Championship since the end of the 2010/11 campaign.
Warriors 19-23 reversal in Cardiff in round 3 ended a nine game unbeaten run against Welsh regions in all competitions.
Glasgow have won their last four matches against Dragons since the Welshmen's 24-23 victory at Rodney Parade in February 2014.
Overall Guinness PRO12 head to head record:
Played 26, NG Dragons won 13, Warriors won 11, and 2 games drawn.
At Rodney Parade, 7:35pm. Live on BBC Wales and BBC ALBA
Referee: Andrew Brace (IRFU, 14th competition game)
Assistant Referees: Frank Murphy (IRFU), Aled Evans (WRU)
Citing Commissioner: Gwyn Bowden (WRU)
TMO: Kevin Beggs (IRFU)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland