The West Walians have lost their last two home games against fellow Welsh regions since they beat Dragons at Parc y Scarlets at the end of October 2015.
Newport Gwent Dragons have recorded just one victory in their last nine fixtures in all competitions: 11-6 at home to Zebre in round 2 of the Guinness PRO12.
Dragons have not beaten a fellow Welsh region on their own soil since visiting Cardiff on Boxing Day 2014.
Scarlets solitary defeat in their last 15 Championship encounters with Dragons was 16-23 at Rodney Parade in September 2013.
Dragons only victory on Scarlets soil since the two regions were formed in 2003 was 30-23 at the old Stradey Park in the PRO12 in September 2007.
Overall Guinness PRO12 head to head record:
Played 26, Scarlets won 21, Dragons won 5.
At Parc y Scarlets, 7.35pm. Live on S4C
Referee: Ben Whitehouse (WRU, 30th competition game)
Assistant Referees: Wayne Davies, Chris Williams (both WRU)
Citing Commissioner: Aurwell Morgan (WRU)
TMO: Jon Mason (WRU)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland