The Scotstoun outfit have reached the final for the first time and could make history by getting past 35-year-old O'Driscoll, who will be bidding for a fourth winners medal in his final match before retiring.
Scottish international Fusaro admits that the former Irish captain, who has competed in 133 Test matches and boasts two Six Nations Grand Slam trophies, will pose a big attacking threat but insists that his side are ready for the challenge.
"It's obviously going to be a very emotional time for him," the 24-year-old told BBC Sport.
"He's a very big threat in attack and defence but their whole team have been playing very well. In their semi-final win against Ulster you could just see the patience they had.
"It took them until the 72nd minute to win the game but they still achieved it and it's something they are very good at - closing out the close games."
The two sides finished first and second in this season's competition and are evenly matched with one head-to-head win each.
Fusaro admits that it will be a close game and is expecting a physical contest, but insists that the prospect of making history will drive his side on.
"We set out at the start of the season to achieve something that no Scottish club's ever done before and now we've got a massive chance to do that.
"It's just a great feeling to be in the final, but we really need to take the next step. It's a chance to make history.
"It's just an incredible opportunity and something we're all really looking forward to.
"Hopefully we'll have a good travelling support over there in Dublin."
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