A new-look half back pairing will see Gareth Anscombe and Lloyd Williams join forces, with the scrum half taking the captaincy.
Wing Alex Cuthbert will start the match while back row Josh Turnbull is also recalled to the side.
Leading try scorer Tom James is named among the replacements while there is also a call-up for hooker Matthew Rees to the bench.
Head Coach Danny Wilson said: "Every time you play Leinster, home or away, it is a tough fixture against a quality outfit.
"We enjoy the surface at home but it's also important we don't concede as many tries as we have at home. It's a fast surface which makes it hard to defend and with Leinster here it should be an entertaining and open fixture.
"Our confidence on our home pitch is high; it's a surface where we have adapted our game and style to suit it. But we're playing against one of the best running teams out there so we know the challenge ahead.
"We want to keep the Arms Park as a real fortress and keep winning here. Hopefully we can use home advantage and our home crowd to get over the line."
Tickets remain on sale NOW for the home clash with Leinster Rugby. Call the Ticket Office on 02920 302030 or click on www.cardiffblues.com/tickets to buy online.
Cardiff Blues: 15 Rhys Patchell, 14 Alex Cuthbert, 13 Cory Allen, 12 Rey Lee-Lo, 11 Blaine Scully, 10 Gareth Anscombe, 9 Lloyd Williams (c); 1 Thomas Davies, 2 Kristian Dacey, 3 Salesi Ma'afu, 4 Jarrad Hoeata, 5 James Down, 6 Josh Turnbull, 7 Ellis Jenkins, 8 Manoa Vosawai
Replacements: 16 Matthew Rees, 17 Bradley Thyer, 18 Taufa'ao Filise, 19 Macauley Cook, 20 Josh Navidi, 21 Tomos Williams, 22 Tom James, 23 Dan Fish
Guinness PRO12 Blues News
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