Head Coach Danny Wilson moves Rhys Patchell to full back for the fixture while Dan Fish will operate on the wing.
The final change is a call-up for loosehead prop Thomas Davies. Back row Josh Turnbull is released from 6 Nations duty with Wales but hooker Kristian Dacey and prop Brad Thyer miss the game through injury.
Wales Under-20 international front row Corey Domachowski and international team-mate Harri Millard could both make their senior debuts after being named among the replacements.
Head Coach Wilson said: "We expect Glasgow to have some good and experienced players released back from Scotland, with no 6 Nations fixtures this weekend, and at home they are dangerous to play.
"Glasgow Warriors hold their home performances in high regard and they are proud of what they do. We know we face a big ask, but it's one that if we can get a result it will do us the world of good in terms of league position and pushing for the top six."
Cardiff Blues: 15 Rhys Patchell, 14 Blaine Scully, 13 Aled Summerhill, 12 Rey Lee-Lo, 11 Dan Fish, 10 Jarrod Evans, 9Tomos Williams; 1 Thomas Davies, 2 Matthew Rees (c), 3 Salesi Ma'afu, 4 Jarrad Hoeata, 5 James Down, 6 Josh Turnbull, 7 Ellis Jenkins, 8 Manoa Vosawai
Replacements: 16 Ethan Lewis, 17 Corey Domachowski, 18 Taufa'ao Filise, 19 Macauley Cook, 20 Josh Navidi, 21 Lewis Jones, 22 Garyn Smith, 23 Harri Millard
Guinness PRO12 Blues News
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