Captain Ken Owens returns to lead the side and he's joined by internationals Gareth Davies, Rob Evans, Jake Ball and John Barclay in the starting XV with Samson Lee named on the replacements bench.
Liam Williams misses out on the clash with a hamstring strain whilst Morgan Allen returns to the number 8 berth after recovering from a foot injury.
Speaking ahead of the derby earlier this week head coach Wayne Pivac said: "Our whole season has been built on improving on last year, we've made no secret about it - we want to improve. One of those improvements is our statue within Wales and we'd like to be King of the group if you like. Highest up in the points table and in doing so finishing in the top four.
"The self-belief is growing in the group, there's a lot for us to play for selfishly, place in Europe like everybody and top four. We're in there but it's a case of improving week on week.
"Ospreys are a very proud team as we all know. They're still within a very good chance of getting in to Europe and upsetting a few teams along the way. It's a massive game for them as it is for us and we're expecting a titanic struggle.
"It's a derby against our close neighbours and there's a lot riding on the game."
Scarlets team to take on Ospreys at Liberty Stadium, Saturday 26th March, kick-off 3pm;
15 Steff Evans, 14 Gareth Owen, 13 Regan King, 12 Hadleigh Parkes, 11 DTH van der Merwe, 10 Dan Jones, 9 Gareth Davies, 1 Rob Evans, 2 Ken Owens ©, 3 Peter Edwards, 4 Jake Ball, 5 David Bulbring, 6 John Barclay, 7 James Davies, 8 Morgan Allen
Replacements: Kirby Myhill, Dylan Evans, Samson Lee, Maselino Paulino, Will Boyde, Aled Davies, Aled Thomas, Harry Robinson
Unavailable for selection: Scott Williams (knee), Josh Macleod (foot), Emyr Phillips (knee), Jack Condy (shoulder), Lewis Rawlins (neck), Tom Williams (shoulder), Steve Shingler (knee), Aaron Shingler (concussion), Liam Williams (hamstring), Tom Price (wrist)
Guinness PRO12 Scarlets News
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