Connacht have lost just once at home this season - going down in their Boxing Day clash with Ulster - but Townsend is adamant that his side can work out the key strategy for success in Galway.
"We know a little more about Connacht having played them on Saturday, and about whether our blend will have to change," he told BBC Scotland.
"But there's something to be said for that group of players to get that second chance because they have that immediate experience of playing against Connacht.
"They were very tough, aggressive, tackled well and tried to move the ball early. They did a couple of things in attack and defence we hadn't seen before.
"We saw enough to know they are a tough team who play with pride and passion and on a dry day we know they are going to move the ball about."
In the history of the Guinness PRO12 no side has ever won an away semi-final, but that is not a fact that concerns Townsend who believes records are there to be broken.
He added: "It would be nice to break the record, we'll have to do our very best to do that. We have experience of winning semi-finals.
"Connacht play with a lot of passion at home, the atmosphere there is like Scotstoun, really noisy.
"As a group we need to stay strong, but I have huge belief in the players and that we can come back with a win."
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