The Liberty Stadium outfit were 57 points ahead at the interval of the 11-try romp, with Keelan Giles, Joe Thomas and Tom Williams all notching hat-tricks in a youthful line-up.
Hugh Gustafson and Dafydd Howells rounded off the win, Ospreys' second of a successful training week after they beat English side Leicester Tigers last Friday.
Even more encouraging for Ospreys was the successful return of Tipuric, and he insists he is now raring to go for the new Guinness PRO12 season.
"I obviously didn't have the nicest of times with the injury," he said. "I had a few, well-documented problems which you wouldn't really have wanted, but everything's good now.
"The Ospreys, Wales and the specialists have all looked after me and been great to me and gone through the right channels. I've had the all clear and I'm looking forward to playing again.
"The first couple of games are always tough while you try to get your match fitness up. It has been a good training camp in Waterloo."
Ospreys face Leicester again in the coming week, and may well field close to a full strength side as they build towards their opening Guinness PRO12 clash against Zebre.
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