The reigning champions finished last season with a won four lost three record against fellow Irish provinces in the Championship.
Ulster Rugby maintained their perfect start to the new Guinness PRO12 campaign with a fifth successive victory, albeit a narrow one, over Ospreys in Belfast on Saturday.
Ulster's only defeat in their last five away games came in last season's semi-final against Leinster at the RDS Arena.
Connacht have beaten Ulster just once in their last twenty encounters: 26-21 at the Sportsground in April 2012.
Overall Guinness PRO12 head to head record:
Played 26, Connacht won 3, Ulster won 22 and 1 game drawn.
At The Sportsground, 7.35pm. Live on TG4 and BBC SPORT NI
Referee: Gary Conway (IRFU, 24th competition game)
Assistant Referees: Dudley Phillips, Leo Colgan (both IRFU)
Citing Commissioner: Wayne Sheridan (IRFU)
TMO: Peter Fitzgibbon (IRFU)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland