The Scotsmen's only defeat to an Italian opponent in their last seven such meetings was 11-19 to Zebre in Parma on 24 October 2015.
Benetton Rugby Treviso have won just one of their last half a dozen Guinness PRO12 matches: 27-11 at home to Newport Gwent Dragons in round 4 this season.
Treviso have not won away from home since beating Zebre 26-16 in Parma in December 2014.
Edinburgh have won their last four fixtures against Treviso since the Italians' 20-16 victory at Stadio Monigo in March 2014.
Treviso's most recent victory in Scotland was against Edinburgh at BT Murrayfield in October 2012.
Overall Guinness PRO12 head to head record:
Played 12, Edinburgh won 8, Treviso won 4.
At BT Murrayfield, 7:35pm. Live on BBC Alba
Referee: Ian Davies (WRU, 52nd competition game)
Assistant Referees: Rhys Thomas (WRU), Dunx McClement (SRU)
Citing Commissioner: John Kirk (SRU)
TMO: Gareth Simmonds (WRU)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland