The Leinstermen's only reversal at Aviva Stadium in the Championship was against Munster in October 2014.
Munster have lost just one of their last seven PRO12 fixtures and that by a single point in 47 against Cardiff Blues in Cork on 9 September.
Munster's only win in their last five encounters with Irish provinces was 9-7 over Ulster in Belfast on 2 January.
Leinster achieved the season's double over Munster in 2015/16 to reverse the two Munster successes the previous season.
The last seven meetings between the two old foes at the headquarters of Irish Rugby have resulted in six Leinster wins and one by Munster.
Overall Guinness PRO12 head to head record:
Played 29, Leinster won 17, Munster won 12.
At Aviva Stadium, 2.05pm. Live on Sky Sports and TG4
Referee: David Wilkinson (IRFU, 45th competition game)
Assistant Referees: Stuart Gaffikin, Richard Kerr (both IRFU)
Citing Commissioner: Eddie Walsh (IRFU)
TMO: Simon McDowell (IRFU)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland