Connacht's leading try scorer Fionn Carr has been named on the right wing while Gavin Duffy moves to full back to allow Irish International Robbie Henshaw switch to the centre.
In the pack, the front five remains unchanged from last week but the back row sees Andrew Browne promoted from the bench to start at blindside flanker while John Muldoon moves to the openside. Eoin McKeon makes up an all-Galway back row wearing the Number 8 jersey.
On the replacements bench, lock Aly Muldowney returns to the fray and 20-year-old Academy back Darragh Leader has been brought in as cover.
Commenting on the team selection and the upcoming game, Head Coach Pat Lam said:
"Despite being boosted by the win on Saturday against the Dragons, we lost a couple of guys through that last game and it's hugely disappointing to have to plan without Dave (McSharry), especially on the back of losing our other midfielders Danie (Poolman), Craig (Ronaldson) and Kyle (Tonetti) to injury.
"Kieran Marmion has had a high work load this season having played in every game and taking part in a two-day national camp earlier this week. So he is named on the bench for tomorrow's game. We're delighted for Frank to achieve his 100th Connacht cap, especially after such a long road to recovery last season.
"Jake (Heenan) joins Willie Faloon on the injured list which is another huge loss to a crucial position for us. But John (Muldoon) has shown in the past that he has the skillset and experience to switch sides in the back row.
"We're really looking forward to the game. These interprovincial games are huge occasions and a source of great pride for the players. It's a massive challenge as Munster are flying high at the top of the PRO12 table, they're topping their own Heineken Cup pool and we haven't beaten them down there since 1967!
"We have shown this season that if we go through the processes and bring heart to our game plan, we can get the outcome we all want. That's what we have to do tomorrow."
Connacht lineup v Munster
15. Gavin Duffy
14. Fionn Carr
13. Robbie Henshaw
12. Eoin Griffin
11. Matt Healy
10. Dan Parks
9. Frank Murphy
1. Brett Wilkinson
2. Jason Harris-Wright
3. Nathan White
4. Mick Kearney
5. Craig Clarke (captain)
6. Andrew Browne
7. John Muldoon
8. Eoin McKeon
Replacements:
16. Dave Heffernan
17. Denis Buckley
18. Rodney Ah You
19. Aly Muldowney
20. George Naoupu
21. Kieran Marmion
22. Jack Carty
23. Darragh Leader
Unavailable/Injured: Jake Heenan, Sean Henry, Michael Swift, Willie Faloon, Mata Fifita, Dave McSharry, Craig Ronaldson, Danie Poolman, Tiernan O'Halloran, Miah Nikora, and Kyle Tonetti.
Munster v Connacht
At Thomond Park , 7.15pm.
Live on TG4
Referee: Dudley Phillips (IRFU, 39th competition game)
Assistant Referees: Sean Gallagher, Eanna O'Dowd (both IRFU)
Citing Commissioner: Gordon Black (IRFU)
TMO: Alan Rogan (IRFU)
Guinness PRO12 Connacht News
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