Browne, younger brother of former Connacht, Leinster and current Oyonnax second row Damian, came through the Connacht Academy system in 2007 and has enjoyed regular game time since then, winning 75 Celtic League caps and playing in both the Amlin Challenge Cup and Heineken European Cup.
The 26-year-old has played at blindside flanker this season but is equally adept in the second row. His power and athleticism have made him something of a lineout specialist and he has been an integral part of the Connacht pack featuring in 10 games so far this season.
Browne will join the elite group of Connacht centurions Michael Swift, John Muldoon, Brett Wilkinson, Gavin Duffy, Ronan Loughney and Frank Murphy who have all represented Connacht over 100 times and are still playing for the province.
The versatile forward last year signed a new two-year contract to remain at the Sportsground until at least the summer of 2015.
Commenting on the impending milestone, Browne said:
"It's a huge, huge honour for me and something you dream of as a young, local lad. It would be fantastic to win my 100th cap against Leinster at the weekend and to mark it with a win over the league champions."