Whoever emerges victorious will likely head up the table and with both teams unbeaten in Europe, they come into the game in fine form.
While Munster's trip to Stade Français was postponed this week, Connacht followed up their epic journey to Russia with a vital win over Brive and are now well-placed ahead of two clashes with Newcastle in December.
That is not the only derby taking place in Ireland this weekend, with Friday's action also featuring a huge encounter between Leinster and Ulster at the RDS.
Currently battling out for fourth place in the GUINNESS PRO12, both will be keen to make up for disappointing starts to their European campaigns.
Ospreys, on the other hand, top their European pool after picking up two losing bonus points away in Clermont, a week after beating Exeter.
That puts them in great shape and they will hoping to carry that form back into the GUINNESS PRO12 after a slow start to the season in the league.
They welcome Cardiff Blues to the Liberty Stadium, and Danny Wilson's team have had plenty of time to prepare since playing their Challenge Cup game against Harlequins last Thursday.
In the round's other fixtures Edinburgh host Newport Gwent Dragons at BT Murrayfield, while reigning GUINNESS PRO12 champions Glasgow Warriors welcome a BenettonTreviso side still chasing a first win of the season.
Finally Zebre, fresh from a thumping win over Worcester in Europe, will be looking to take that form into their clash with Scarlets in Llanelli, however Wayne Pivac's side are unbeaten at home in the league this season.
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Guinness PRO12 Zebre News
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