While Cullen's men might have bowed out of the European Rugby Champions Cup they are alive and well in the GUINNESS PRO12 after nine wins from 11 matches.
That leaves them sitting just two points behind leaders Scarlets but with a game in hand on their Welsh rivals while the fortunes of Newport Gwent Dragons are almost completely opposite, with Lyn Jones' troops second from bottom.
However, Cullen says that a host of injuries to his side make the trip to Wales anything but a formality and knows they will need to pull together to ensure a positive result.
"Isa Nacewa last week had a small procedure done to his knee so he'll be out for two to three weeks," said Cullen.
"Royce Burke-Flynn, who has been with us this season, had neck surgery last week so he will be out for four months.
"Of some of those other players, Mike Ross, Cian Healy, Collie O'Shea they are rehabbing away after a couple of niggles and are probably a couple of weeks away yet.
"Tom Denton was due to be involved in the game at the weekend, he broke down in training on Thursday . . . he'll be a couple of weeks.
"Those longer-term guys coming back - Hayden Triggs is very close, Mick Kearney, again, probably three to four weeks away as is Jack Conan. Ed Byrne, Gav Thornbury are probably a little bit longer.
"It's a big challenge for us this Friday against the Dragons. It's fair to say they are not going to be missing anywhere near that number of players. So it is all hands on deck."
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Guinness PRO12 Leinster News
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