Brown, 25, made his Edinburgh Rugby debut in September 2010 against Cardiff Blues, and has since amassed 83 caps and 60 points in the black and red shirt.
He plays in a backline that sees two players promoted from the bench to start against seventh place Ospreys, with Sean Kennedy slotting in at scrum-half and Dougie Fife moving onto the right wing, in place of Nathan Fowles and Damien Hoyland, respectively.
There are two changes to the starting forward pack as Allan Dell moves into the loosehead prop berth for Rory Sutherland, who is with the Scotland national team, to join John Andress and Neil Cochrane in the front-row.
The combination of Anton Bresler and Ben Toolis continues at lock.
Jamie Ritchie moves into the blindside berth in place of Mike Coman, who is ruled out with an injured calf, and is joined by Cornell Du Preez and Hamish Watson -who both recently passed the half-century cap mark for Edinburgh - in the back-row.
Phil Burleigh partners scrum-half Kennedy to form the half-back duo, as Sam Beard and Michael Allen continue in midfield.
The newly re-signed Tom Brown starts on the left wing, with Fife donning the 14 shirt on the right flank, and Greig Tonks remaining at full-back.
There are five additions to the bench with lock Grant Gilchrist set to return after a long spell out through injury, and scrum-half Sam Hidalgo-Clyne recalled from international duty to travel to Ospreys. After a period away with Scotland 7s, centre Chris Dean is also included in the match-day squad, as is prop Grant Shiells and back-row Magnus Bradbury.
Head Coach Alan Solomons said: "This week will be an even tougher test against a powerful Ospreys team playing at home, and we need to rise to the challenge which lies ahead."
Players not considered due to injury: Mike Coman (calf), Nasi Manu (neck), Fraser McKenzie (neck), Andries Strauss (knee and ankle) Jade Te Rure (knee).
Absent on international duty: Alasdair Dickinson, Ross Ford, WP Nel, John Hardie, Matt Scott, Stuart McInally, Rory Sutherland.
Tom Brown quotes:
Speaking on his new contract Tom Brown said: "I'm delighted that I've managed to settle another deal with Edinburgh, and can look forward to another year at the club.
"On a personal note, I'm an Edinburgh boy and it's always been a dream to represent the club, so it's great that I can now look forward to next season at BT Murrayfield.
"My time at the club so far has been brilliant, and, at this point in my career, there's no place I would rather be than Edinburgh."
Head Coach Alan Solomons said: "We're delighted that Tom will be with us for another year. He is a valuable member of the squad, a great bloke and a good team man.
"I look forward to continuing to work with him."
Edinburgh Rugby v Ospreys
Liberty Stadium, Friday 19 February, kick-off 7.05pm - live on BBC 2 Scotland
15 Greig Tonks
14 Dougie Fife
13 Michael Allen
12 Sam Beard
11 Tom Brown
10 Phil Burleigh
9 Sean Kennedy
1 Allan Dell
2 Neil Cochrane CAPTAIN
3 John Andress
4 Anton Bresler
5 Ben Toolis
6 Jamie Ritchie
7 Hamish Watson
8 Cornell Du Preez
Substitutes
16 George Turner
17 Grant Sheills
18 Simon Berghan
19 Grant Gilchrist
20 Magnus Bradbury
21 Sam Hidalgo-Clyne
22 Chris Dean
23 Blair Kinghorn
Guinness PRO12 Edinburgh News
63x46.png){kind=logo}