The only other change is also in the back-three, where 19-year-old Blair Kinghorn, will make his third start for the club at full-back.
Joining Hoyland and Kinghorn in the back three is Tom Brown, who starts on the left wing.
In an otherwise unchanged backline, Sam Beard and Michael Allen continue at centre, while Sean Kennedy and Phil Burleigh remain as the half-back duo.
Last week's try-scorer, Allan Dell, packs down at loosehead prop, with John Andress taking up the tighthead berth, and Neil Cochrane captaining the team from hooker.
Ben Toolis is released from the national team to don the number five shirt, and continues his well-established partnership with Anton Bresler in the second-row.
Jamie Ritchie and Hamish Watson start in the back-row, either side of Cornell Du Preez, who completes the pack at number eight.
Head Coach Alan Solomons said: "With international call-ups and injury this will yet again be a test of the strength in depth of our squad. Our players are looking forward to meeting the challenge this presents."
Players not considered due to injury: Mike Coman (calf), Jack Cuthbert (knee), Grant Gilchrist (arm),Nasi Manu (neck), Fraser McKenzie (neck), Andries Strauss (knee and ankle) Jade Te Rure (knee) Grant Gilchrist (arm).
Absent on international duty: Alasdair Dickinson, Ross Ford, Sam Hidalgo-Clyne, WP Nel, John Hardie, Matt Scott, Stuart McInally, Rory Sutherland.
Edinburgh Rugby v Scarlets
BT Murrayfield, Sunday 28 February (kick-off 2.05pm) - live on BBC 2 Scotland
15. Blair Kinghorn
14. Damien Hoyland
13. Michael Allen
12. Sam Beard
11. Tom Brown
10. Phil Burleigh
9. Sean Kennedy
1. Allan Dell
2. Neil Cochrane CAPTAIN
3. John Andress
4. Anton Bresler
5. Ben Toolis
6. Jamie Ritchie
7. Hamish Watson
8. Cornell Du Preez
Substitutes
16. George Turner
17. Grant Sheills
18. Simon Berghan
19. Alex Toolis
20. Magnus Bradbury
21. Nathan Fowles
22. Chris Dean
23. Dougie Fife
Guinness PRO12 Edinburgh News
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