Up front, hooker Dave Heffernan has been handed his first start of the season in the absence of the injured Tom McCartney. With Denis Buckley ruled out, returning Ireland international Finlay Bealham comes in at loosehead while Conor Carey remains at tighthead after having made his debut against Edinburgh last week.
Galway man Andrew Browne returns from injury to make his first appearance of the season and partners Ultan Dillane in the second row. Quinn Roux is unavailable this week having picked up a knock while training with Ireland earlier in the week.
Changes to the replacements bench see Shane Delahunt in line to make his season debut while uncapped, Academy scrum half Steven Kerins and new arrival and utility back Stacey Ili have been named in their first match day squads.
20-year-old Kerins, from Sligo, has been training with the senior squad since pre-season having impressed with the Ireland U20's side in June's World Rugby U20 Championship.
Commenting on the team selection and the upcoming game, Pat Lam said:
"We've been hit with a good few injuries to our senior squad this week, and have had to make changes to the side as late as this morning. Despite all the different disruptions, we are all really excited by the challenge we face at home against Ulster.
"Ulster are a well-coached side with quality players across the park. We know they will come here full of confidence after the start that they've had and will be targeting this game to continue their impressive run.
"As long as we continue our day-to-day improvement in team performance, we will give ourselves a chance to get the points on offer."
Connacht team to face Ulster, Friday 7th October, the Sportsground, 7:35pm
(Connacht caps in brackets)
15 Tiernan O'Halloran (105)
14 Niyi Adeolokun (36)
13 Bundee Aki (45)
12 Craig Ronaldson (51)
11 Cian Kelleher (3)
10 Jack Carty (58)
9 Caolin Blade (24)
1 Finlay Bealham (61)
2 Dave Heffernan (61)
3 Conor Carey (1)
4 Ultan Dillane (31)
5 Andrew Browne (144)
6 Eoin McKeon (89)
7 Jake Heenan (36)
8 John Muldoon (captain) (279)
Replacements:
16 Shane Delahunt (17)
17 Ronan Loughney (187)
18 JP Cooney (31)
19 Lewis Stevenson (4)
20 James Connolly (20)
21 Stephen Kerins (0)
22 Shane O'Leary (18)
23 Stacey Ili (0)
Injured/Unavailable: Tom McCartney, Denis Buckley, Dominic Robertson-McCoy, Ivan Soroka, Ben Marshall, Quinn Roux, Nepia Fox-Matamua, Sean O'Brien, Eoghan Masterson, Kieran Marmion, John Cooney, Marnitz Boshoff, Rory Parata, Eoin Griffin, Peter Robb, Matt Healy, Josh Rowland, Darragh Leader, Ciaran Gaffney, Cormac Brennan.
Connacht v Ulster
Friday 7th October
At The Sportsground, 7.35pm .
Live on TG4 / BBC Northern Ireland
Referee: Gary Conway (IRFU, 24th competition game)
Assistant Referees: Dudley Phillips, Leo Colgan (both IRFU)
Citing Commissioner: Wayne Sheridan (IRFU)
TMO: Peter Fitzgibbon (IRFU)