That will secure the defending champions a play-off finish but is unlikely to be enough to avoid a semi-final against Ulster at Ravenhill with the possibility of finishing up back in Dublin for the final.
There again, it could just as easily be the other way round. Irrespective of how it works out, no team can ever have faced as formidable a run-in to any Grand Final as the one facing the Ospreys.
It brings the ultimate challenge - four successive away matches, assuming they go the distance, and perhaps two of them against Leinster, the best in Europe until Clermont usurped their title before Christmas.
Should the holders fail to survive the equine equivalent of jumping Beechers Brook four times in a row, it will not be for any lack of conviction based on the experience of having been there and done most of it.
When it comes to picking off the big teams in the big matches, the Welsh birds of prey have a habit of finishing top of the pecking order.
They have done so to spectacular effect, beating Leinster at the RDS in last year's final just as they had beaten them at the same place in the final two years earlier.
Nothing daunts the Ospreys, not even the prospect of seeing the then Heineken Cup holders off their own premises at Ballsbridge.
They have since widened that capacity for winning at the toughest of places by taking it to the other side of the Irish border.
The Ospreys are the only side to have beaten Ulster at Ravenhill in the RaboDirect PRO12 all season - 16-12 in early February with prop Ryan Bevington claiming the only try of the match.
If Ulster were far from full-strength for a fixture played during the second weekend of the Six Nations, then the Ospreys were similarly hit by international demands.
They have lost one of their last 11 and yet they go into the penultimate round of the regular season with no margin for error if they are not to be run out of the top four by the neighbouring Scarlets.
They finish up in the comfort of their own ground, against the Blues on Saturday followed by Treviso on May 3.
Their position, fifth behind the Ospreys only by virtue of a markedly inferior points-difference, demands that they win both and hope their rivals stumble on the road.
The Scarlets underlined their determination to be one of the chosen four by derailing the Warriors' bandwagon to the tune of 29-6 - more than enough to leave the Glaswegians pointless for the first time since Munster made light work of them at the start of December.
They got more than their own back in the reverse fixture last time out at home, a win on the monumental scale of six tries and 51 points.
Now Scotstoun is bracing itself for a much bigger occasion on Friday, so big that a temporary 4,200-seater stand has been assembled to meet public demand.
It raises capacity to almost 10,000 for a match laden with possibilities. For the Warriors, it will either guarantee them a play-off place or send them into the last match in Galway searching for an 11th-hour reprieve at the expense of Connacht.
The Ospreys know that defeat would put them in danger of being counted out and they will hardly be relying on the Blues doing them an unwitting favour at the Scarlets on Saturday.
They also know they missed a trick by falling short of a try-bonus point win against Treviso in Swansea last week.
At least the title defence is in their own hands, something which seemed improbable after they lost their first three matches, dropping 13 points from a maximum 15.
Leinster, back on track for a home semi-final after beating Munster, go to Zebre where the Italians try for the 21st time to break their RaboDirect PRO12 duck. Yet despite that, only one team has gone there and come home with all five points - Glasgow in February.
Even so, it could hardly provide a greater contrast to Munster at Thomond Park. How typical of Brian O'Driscoll to come up with the winning try after 26 phases towards the end of his first match for 12 weeks.
One Lions captain had put it across another, Paul O'Connell, four games into a comeback might enough to remind province and country what it has missed.
Nobody ought to be the least bit surprised should he be the chosen one for the Lions tour of Australia, just as he was for the last one in South Africa four years ago.
Only Martin Johnson has done it twice and by the time head coach Warren Gatland names his man at the end of the month, O'Connell will have taken Munster into their most difficult foreign assignment of all.
Taking care of Clermont in the European Cup semi-final may be the ultimate ask but then nobody asks more of themselves than Munster, all the more so given that they have fallen a long way short in the RaboDirect PRO12.
Leinster have a semi-final of their own, Biarritz in the Amlin Cup with the winner to meet Perpignan or Stade Francais in the Dublin final. All four have appeared in at least one Heineken final.
All they need to avoid between now and then is to avoid an Italian banana skin.
Barring a giant-killing of Goliath proportion, Joe Schmidt's team will clinch the security of a home semi-final on Sunday should the Warriors finish up empty-handed against Welsh opposition for the second week running.