Cuthbert, a member of the British & Irish Lions this summer, missed the game through injury but returned for the Wales' match against Australia.
But the pair will put national allegiances to one side on Thursday as the Dragons welcome the Blues to Rodney Parade for the first of a Welsh double header.
At just 5ft 11ins, Amos is considerably smaller than the 6ft 6ins frame of Cuthbert but the young wing was not letting that deter him.
"It will be a good challenge," Amos told WalesOnline.
"I like pitting myself against the best and he is a Lions try-scoring Test winger and one of the best in the world, so it will be nice to see how I go against him.
"Hopefully I can stop him getting on the scoresheet. He does pop up with quite a few tries.
"Alex is obviously an amazing player, but with someone like him you know a bit more what he is going to do compared to the likes of Jordan Williams at the Scarlets or Shane Williams.
"You know what is coming really. But I don't really have a preference to be honest, when it comes to big or small opponents.
"I think it's nice to get your head around both and learn from both when you play against them.
"Alex is big, but he's also very quick over the first 40 metres."
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