Craig Gilroy is one of seven Ireland internationals in the side and returns to the starting XV at fullback. He is joined in the back three by Tommy Bowe who switches to the right wing and Michael Allen who starts on the left.
Darren Cave maintains his place at outside centre and is joined in midfield by last year's Hughes Insurance Academy Player of the season, Stuart McCloskey, who makes his first start of the season.
Paddy Jackson, who scored 14 points in the win over Cardiff, starts at outhalf and is partnered by Michael Heaney in the half-backs.
Up front, there is a whole new front row wi th Callum Black named at loosehead, Rob Herring selected at hooker and Declan Fitzpatrick, who has recovered from injury, starting at tighthead prop.
In the second row, Franco van der Merwe is joined by Neil McComb who starts his first match of the season.
In the back row, ex Lansdowne player, Clive Ross, starts his first competitive match for the Province and is selected at openside, Roger Wilson captains the side from blindside and Nick Williams starts at Number 8.
Rory Best, Ruaidhri Murphy, Wiehahn Herbst, Lewis Stevenson and Mike McComish are named on the bench as are backs Paul Marshall, Ian Humphreys and Andrew Trimble.
The game is live on BBC 2 Northern Ireland.
Ulster team to play Zebre, Stadio XXV Aprile, Saturday 27th September (kick-off 16:00 / 15:00 UK and Ireland) - live on BBC 2 Northern Ireland:
15. Craig Gilroy
14. Tommy Bowe
13. Darren Cave
12. Stuart McCIoskey
11. Mich ael Allen
10. Paddy Jackson
9. Michael Heaney
1. Callum Black
2. Rob Herring
3. Declan Fitzpatrick
4. Neil McComb
5. Franco van der Merwe
6. Roger Wilson (Captain)
7. Clive Ross
8. Nick Williams
Replacements
16. Rory Best
17. Ruaidhri Murphy
18. Wiehahn Herbst
19. Lewis Stevenson
20. Mike McComish
21. Paul Marshall
22. Ian Humphreys
23. Andrew Trimble
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland