The 24-year-old Scottish international will return to Murrayfield having missed all of Edinburgh's three games this season through injury.
He is one of eight changes named by head coach Alan Solomons in the wake of a nine-try 62-13 defeat to Ospreys at the Liberty Stadium last Sunday.
And Gilchrist admits that every player will be under scrutiny after such a chastening loss.
"We can't beat about the bush. It's got to look as though we are a team who are desperate because that's what it is," Gilchrist told the Edinburgh Evening News.
"The result is huge, but first and foremost there is a group of players with a point to prove. We've got to see that."
Scarlets will take to Murrayfield off the back of 43-0 win against Benetton Treviso last Saturday, their first win of the season following a draw to Ulster and a 42-12 loss to Leinster.
"Scarlets are good in open play," added Gilchrist. "Watching their last few games, if they get a sniff of open field rugby they are top quality. They handle well from one to 15.
"As soon as a game breaks up they are dangerous. We need to look at our defence that was far from perfect. It'll start there."
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