An all new front row sees Dave Kilcoyne and BJ Botha pack down on either side of Kevin O'Byrne as the 23 year old UL Bohs man makes his second PRO12 start.
Dave Foley retains his position in the second row alongside Billy Holland who comes in to make his fourth league start of the season.
Following a 16 minute appearance from the bench last weekend, Peter O'Mahony returns to the starting line-up and captains the side at 6 while Tommy O'Donnell remains at openside with CJ Stander switching to 8 for the round 6 encounter.
In the half backs, man of the match against Leinster - Conor Murray will again start at scrum half with JJ Hanrahan making his first start of the season at 10.
Ivan Dineen and Andrew Smith form the centre partnership at 12 and 13 respectively, while Gerhard van den Heever comes in to join Simon Zebo and Felix Jones in the back three.
The replacements see the inclusion of Argentinian hooker Eusebio Guinazu for his first time in a PRO12 squad while Donncha O'Callaghan and Johne Murphy also return to Munster's matchday squad.
Munster: Felix Jones, Gerhard van den Heever, Andrew Smith, Ivan Dineen, Simon Zebo; JJ Hanrahan, Conor Murray; Dave Kilcoyne, Kevin O'Byrne, BJ Botha; Dave Foley, Billy Holland; Peter O'Mahony - capt, Tommy O'Donnell, CJ Stander.
Replacements: Eusebio Guinazu, James Cronin, Stephen Archer, Donncha O'Callaghan, Robin Copeland, Duncan Williams, Ian Keatley, Johne Murphy.
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland