The 26-year-old is one of five uncapped players selected in Ireland's 37-man squad to face South Africa, Georgia and Australia.
But O'Mahony has no doubt that the lock has the ability and temperament to handle the pressures that come with international rugby and believes his GUINNESS PRO12 performances are a testament to that.
"Dave's been up there a couple of times and he knows where it's at," O'Mahony told the Irish Examiner.
"He drives standards here as well so I don't think there'll be any fear for him.
"I think 'Foles' has been impressive for the last 12, 18 months.
"He's really grown into things, I'd say he's a world class lineout operator and he's learning all the time around the pitch, just muscling up and putting in big performances and backing them up week in, week out, which is important."
Follow us on Facebook, join the conversation on Twitter, sign up to our YouTube channel for extensive match highlights and sign up for our newsletter for regular updates on the GUINNESS PRO12