First, table-topping Glasgow host Ulster in a re-match of last weekend's clash, where a Finn-Russell inspired Warriors coasted to victory.
The hosts are chasing their first PRO12 title while Ulster have the added incentive of a home final should they end Glasgow's 100 per cent home record in the competition this season.
Click here to get your hands on tickets and witness a memorable contest.
And once the dust has settled in Scotland, attentions swiftly turn to Limerick where two of the competition's most successful clubs will do battle.
Ospreys, with four PRO12 titles to their name, visit Munster, who boast three - and they could hardly have been more evenly-matched throughout the season.
Ospreys completed a league double over the Munstermen during the regular season but Anthony Foley's side finished one point better off in the table, earning home advantage in the process.
Click here to book your tickets and see if the Welsh region will complete their hat-trick or fall short of a place in the Final.
2014/15 GUINNESS PRO12 Play-Offs
Play-Off 1: Friday 22nd May at 19:45 - Scotstoun
Glasgow Warriors v Ulster
Ticket Details - http://pro12rug.by/HQK1Jk
Play-Off 2: Saturday 23rd May at 14:30 - Thomond Park
Munster v Ospreys
Ticket Details - http://pro12rug.by/B2DiDv
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Guinness PRO12 Ulster News
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