The campaign begins on Friday September 4 with last season's beaten semi-finalists - Ulster and Ospreys -going head-to-head at the Kingspan Stadium, and Leinster visiting Edinburgh.
Scarlets go to Scotstoun the following day, while Munster host Benetton Treviso, Zebre travel to BT Sport Cardiff Arms Park to take on the Blues and Connacht clash with Newport Gwent Dragons on the opening weekend.
The festive period sees the return of the 1872 Cup, with Edinburgh and the Warriors meeting at BT Murrayfield on December 27 and then again at Scotstoun on January 2.
And there are plenty of other local derbies across rounds 10 and 11, with four all-Welsh clashes, four all-Irish encounters and Benetton Treviso locking horns with Zebre twice in quick succession.
The final round of regular-season action will take place across the weekend of May 6-8 but for the competition's top four sides, the run-in will have only just begun.
Two weeks later sees the play-offs kick off, while the GUINNESS PRO12 Final will be the following weekend, when the champions will lift the coveted trophy.
Follow us on Facebook, join the conversation on Twitter, sign up to our YouTube channel for extensive match highlights and sign up for our newsletter for regular updates on the GUINNESS PRO12
63x46.png){kind=logo}