At full back will be Jayden Hayward and on the wings Ludovico Nitoglia and Simone Ragusi. Among the backs, Tommaso Iannone and Enrico Bacchin are in the centres.
The half backs are completely new with Chris Smylie at scrum half and Luke Mclean as fly-half.
Matteo Zanusso, with Rupert Harden and Davide Giazzon will make up the front row.
The Locks will be Tom Palmer and Marco Fuser. Finally Francesco Minto, with Dean Budd and Braam Steyn will complete the XV chosen by Casellato.
The fly-half Luke Mclean said: " On Monday in the meeting we realised our mistakes and how not to repeat them, but we must look ahead and forget what happened on Saturday."
Benetton Rugby:
15 Jayden Hayward, 14 Ludovico Nitoglia, 13 Tommaso Iannone, 12 Enrico Bacchin, 11 Simone Ragusi, 10 Luke Mclean, 9 Chris Smylie, 8 Abraham Steyn, 7 Dean Budd, 6 Francesco Minto , 5 Tom Palmer, 4 Marco Fuser, 3 Rupert Harden 2 Davide Giazzon ( C ), 1 Matteo Zanusso.
Replacements:16 Luca Bigi, 17 Alberto De Marchi, 18 Simone Ferrari, 19 Teofilo Paulo, 20 Jean-Francois Montauriol, 21 Robert Barbieri, 22 Alberto Lucchese, 23 Andrea Pratichetti.
Coach: Umberto Casellato
Unavailable: Ornel Gega, Alberto Sgarbi, Angelo Esposito, Luca Morisi, Salesi Manu.
Referee: Dudley Phillips (IRFU, 53rd competition game)
Assistant Referees: Gwyn Morris, Gareth John (both WRU)
Citing Commissioner: Jeff Mark (WRU)