In the front row the injury forced withdrawal of James Cronin sees Dave Kilcoyne start at loose-head and as expected BJ Botha has overcome the flu in time to make a return to the starting line-up.
Mark Chisholm is introduced in the second row and with Tommy O'Donnell returning to the backrow Jack O'Donoghue makes the positional switch to blindside, with Captain CJ Stander continuing at 8.
There are three changes to the backline as Ian Keatley joins Tomás O'Leary in the halfbacks while Lucas Gonzalez Amorosino and Ronan O'Mahony are both introduced out wide.
Academy player Rory Scannell, who signed a two-year senior contract earlier this week, continues his midfield partnership with Francis Saili while Andrew Conway remains at fullback.
Replacement scrumhalf Duncan Williams is in line to become the ninth player in the current squad to reach the milestone of 100 appearances for the province if sprung from the bench this weekend.
Munster: Andrew Conway; Ronan O'Mahony, Francis Saili, Rory Scannell, Lucas Gonzalez Amorosino; Ian Keatley, Tomás O'Leary; Dave Kilcoyne, Mike Sherry, BJ Botha; Dave Foley, Mark Chisholm; Jack O'Donoghue, Tommy O'Donnell, CJ Stander Capt.
Replacements: Niall Scannell, John Ryan, Mario Sagario, Billy Holland, Robin Copeland, Duncan Williams, Tyler Bleyendaal, Denis Hurley.