It is the same old story for 25-year-old Gilchrist, with the injury coming in his first game back after a four-month layoff form a groin injury sustained during the 2015 Rugby World Cup.
Gilchrist had also spent the eight months before the World Cup out of action having suffered complications whilst recovering from a broken arm.
A spokesman for Edinburgh said: "Edinburgh Rugby is disappointed to report that lock Grant Glichrist sustained a fracture to a long bone in his forearm during a collision in Friday night's GUINNESS PRO12 match against Ospreys at the Liberty Stadium.
"Gilchrist has seen a specialist and will undergo surgery today [Monday].
"The injury sustained is not to the same bone that required medical attention prior to Rugby World Cup 2015."
To buy tickets for the GUINNESS PRO12 Grand Final click here. Also follow us on Facebook, join the conversation on Twitter, sign up to our YouTube channel for extensive match highlights and sign up for our newsletter for regular updates on the GUINNESS PRO12.