Elsewhere, Dave Kilcoyne will make his first start of the season in the front row while the return of Dave O'Callaghan at 6 sees captain Billy Holland - the PRO12's leading tackler to date - revert to the second row.
The final change comes in the back three with Ian Keatley to start at full back. One of only three players to have scored in excess of 1000 points in the PRO12 (1266), Keatley needs just 5 points to reach the 1000 mark for Munster across all competitions.
Should he appear from the bench, recent academy graduate and Ireland Men's 7s representative Alex Wotton will make his first competitive appearance.
Successfully rehabbing a neck injury, Stephen Archer is included in the matchday squad for the first time this season.
Munster XV: Ian Keatley; Darren Sweetnam, Keith Earls, Cian Bohane, Ronan O'Mahony; Tyler Bleyendaal, Conor Murray; Dave Kilcoyne, Niall Scannell, John Ryan; Jean Kleyn, Billy Holland Capt.; Dave O'Callaghan, Jack O'Donoghue, CJ Stander.
Replacements: Duncan Casey, James Cronin, Stephen Archer, Donnacha Ryan, Conor Oliver, Duncan Williams, Dan Goggin, Alex Wootton.
Tickets will be available to purchase at the stadium. Adult tickets from €20 and Family tickets from €40 (2 adults & 2 juniors) can also be purchased online via Ticketmaster, from the Munster Rugby Ticket Offices at Irish Independent Park and Thomond Park, or by calling 0818 719 300.
Guinness PRO12 Munster News
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