Should they feature from the bench, academy hooker Vincent O'Brien and Young Munster scrum-half Abrie Griesel will make their senior debuts for the province.
Achieving interprovincial success with Munster U20 last season, O'Brien represented Ireland at this year's World Rugby U20 Championship while Griesel, a former South Africa U20 representative, has trained with the squad in recent months.
A number of internationals are unavailable for selection, and in managing player load Tyler Bleyendaal will also miss the round 7 encounter.
Munster XV: Andrew Conway; Darren Sweetnam, Jaco Taute, Rory Scannell, Ronan O'Mahony; Ian Keatley, Duncan Williams; Dave Kilcoyne, Niall Scannell, John Ryan; Donnacha Ryan, Billy Holland; Peter O'Mahony Capt., Tommy O'Donnell, Jack O'Donoghue.
Replacements: Vincent O'Brien, Brian Scott, Stephen Archer, Darren O'Shea, Robin Copeland, Abriel Griesel, Alex Wootton, Dan Goggin.