Zebre won their most recent game in Parma 47-22 against Dragons in round 22 last season but have not won successive matches at the venue since last October.
Cardiff Blues only reversal in their last nine Guinness PRO12 fixtures was 27-40 to Ospreys at 'Judgement Day' in April.
Blues have won on just one of their last seven visits to Italy in the Guinness PRO12: 41-26 over Zebre in Parma in September 2014.
The two sides have met on eight previous occasions with Zebre recording three victories to equal their best record against one opponent in the Championship, shared with Edinburgh and Treviso. .
Overall Guinness PRO12 head to head record:
Played 8, Zebre won 3, Blues won 5.
At Stadio Sergio Lanfranchi, 5.05pm local time (4.05pm Ireland & UK)
Referee: David Wilkinson (IRFU, 44th competition game)
Assistant Referees: Frank Murphy (IRFU), Luca Trentin (FIR)
Citing Commissioner: Marco Cordelli (FIR)
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland