Benetton Rugby will play at 19.45 local (live on TG4), the match is entrusted to Scottish referee Lloyd Linton.
Among the backs, there is the return of the right centre Tommaso Iannone with his rolemate Enrico Bacchin. On the wings are Ludovico Nitoglia and Andrea Pratichetti.
There is a debut for the New Zealander Chris Smylie and with Sam Christie deployed as fly-half.
In the back row, new players Braam Steyn and Robert Barbieri, with Dean Budd.
The whole second row is new with Duncan Naude and Tom Palmer.
The captain is loose head prop Alberto De Marchi, Rupert Harden at tight head prop and the permit player Roberto Santamaria as hooker.
Benetton Rugby: 15 Jayden Hayward, 14 Ludovico Nitoglia, 13 Tommaso Iannone, 12 Henry Bacchin, 11 Andrea Pratichetti, 10 Sam Christie, 9 Chris Smylie; 1 Alberto De Marchi ©, 2 Roberto Santamaria, 3 Rupert Harden, 4 Duncan Naude, 5 Tom Palmer, 6 Robert Barbieri, 7 Dean Budd, 8 Braam Steyn
Replacements: 16 Luke Bigi, 17 Zanusso Matthew, 18 Simone Ferrari, 19 Phillip Gerosa, 20 Jean-Francois Montauriol, 21 Marco Barbini, 22 Alberto Lucchese, 23 Simone Ragusi