From the bench there could be first competitive Scarlets action for exciting young half-back pairing Tavis Knoyle and Dan Newton.
And the Scarlets welcome back Lions hero, Matthew Rees who is on the bench.
Scarlets head coach Nigel Davies said the clash against the Blues would be an intense affair. He said: "If we look back to last season, the Blues didn't have the strongest of starts and people were writing them off after the first three weeks. But we all saw what they were able to do after that.
"Form doesn't count for much in these types of encounters - particularly Welsh derbies like this one, the first of the season. We have only won one game ourselves, it's going to be pretty intense stuff - it will be about desire and I am sure the Blues are going to be desperate for a win."
The Scarlets have performed well against the Blues in recent years and did the double last season. The teams have met 12 times since the advent of regional rugby, with the Scarlets winning eight and losing four.
For Saturday's game, Coach Davies has opted to rest Lions fly-half Stephen Jones as a precaution to protect a minor ankle injury picked up in the past week and will rest Rhys Thomas following a cut to his knee which needed stitches this week.
Fellow Lion Matthew Rees starts on the bench - his first time in a Scarlets jersey since the summer's South African tour.
Davies said he was keen to ensure that Rees and Jones were given sufficient time to get back into rugby with the region. He said: "We have to be very careful with our Lions; they've come back from a hugely intense Test series and it does take time to re-adapt to the regional game."
Acknowledging Jones as one of the top stand-offs in the world, Davies said the Scarlets have erred on the side of caution this weekend.
He said: "Their welfare is paramount, because there are key stages in the season where you want your top players firing on all cylinders.
"Obviously, the Magners League is important to us as it's a hugely competitive competition but we'll still look to peak in the European competition and that has been our primary focus.
"It's great to have the experience of Matthew to call on this weekend; he's been working well with us for the past three weeks now."
Coach Davies said the contest between Jamie Roberts and rising Wales and Scarlets star Jonathan Davies would be one to watch.
He said: "Jamie Roberts will pose a big threat; it'll be a really interesting battle between him and Jonathan Davies. That's something I'm looking forward to and I'm sure everybody else is too.
"There are similarities in many ways. Jamie has done exceptionally well, he's huge and he has the ability to take the ball up and off-load through the tackle. Jon has a few strengths of his own and I think that'll make for a great contest on Saturday."
Davies said the Scarlets centre had grown in confidence and stature since returning from the Wales tour this summer.
He said: "It has been a lot to do with exposure for Jon. Last season was the first he'd played in a string of games week in week out - it takes some getting used to, particularly at the level he was playing at.
"We've spent a lot of time working with him because he has got that great potential. He grew again on the Welsh tour and that gave him a lot of confidence. He has gone up a couple of notches since coming back to the Scarlets and it's all very positive for Jon at the moment."
Scarlets: 15 Daniel Evans, 14 Sean Lamont, 13 Gareth Maule, 12 Jonathan Davies, 11 Mark Jones (c), 10 Rhys Priestland, 9 Martin Roberts, 1 Iestyn Thomas, 2 Ken Owens, 3 Deacon Manu, 4 Lou Reed, 5 Dominic Day, 6 Simon Easterby, 7 Richie Pugh, 8 David Lyons. Reps - 16 Phil John, 17 Matthew Rees, 18 Vernon Cooper, 19 Josh Turnbull, 20 Tavis Knoyle, 21 Dan Newton, 22 Lee Williams.
Cardiff Blues v Scarlets Magners League, Cardiff City Stadium, Saturday, September 26, 6.30pm.
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