In the pack, Ed O'Donoghue steps in for Ryan Caldwell, who is currently rehabbing after an injury received in last weekend's game.
Clinton Schifcofske replaces an injured Bryn Cunningham at full-back, while Daren Cave partners Ian Whitten in the centre.
Ulster's newest signing Tamaiti Horua, starts his first match on the bench. Chris Henry will once again captain the Ulster side in Rory Bests absents.
Commenting ahead of Saturday's game, Ulster Assistant Coach Jeremy Davidson said: "We all know that Ospreys are a star-studded side and we are looking for a big performance this week.
"You just have to look at the Ospreys squad to see what strength and depth they have. Pick any of the players and they have a strong team, so we know that Liberty Stadium is going to be a big ask.
"We will go there primarily to look for a performance and hopefully we can pull something out. In that respect we are hoping to put a lot of things straight after the disappointment of last week.
"All the players have worked their socks off in training and are in the best physical condition they have ever been. We will be looking forward to getting our international players back into the team soon; as there is no doubt their return can bring performances up a level"continued Davidson.
Ulster Team:
(1-8) Bryan Young, Andi Kyriacou, Brendon Botha, Dan Tuohy, Ed O'Donoghue, Chris Henry, Willie Faloon, Robbie Diack
(15-9) Clinton Schifcofske, Timoci Nagusa, Darren Cave, Ian Whitten, Simon Danielli, Ian Humphreys, Isaac Boss
Replacements:
(16-22) Nigel Brady, Declan Fitzpatrick, Tamaiti Horua, Thomas Anderson, Cillian Willis, Niall O'Connor, Jonny Shiels
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland