Centre Niva Ta'auso (hand), props Brett Wilkinson (finger) and Robbie Morris (back) have been ruled out of this clash.
Into their places from the side which picked up a bonus point against the Ospreys on the opening weekend of the season, come Troy Nathan, Jamie Hagan and Ronan Loughney.
Connacht: Gavin Duffy; Brian Tuohy, Troy Nathan, Keith Matthews, Fionn Carr; Ian Keatley, Frank Murphy; Ronan Loughney, Sean Cronin, Jamie Hagan; Andrew Browne, Bernie Upton; John Muldoon, Ray Ofisa, Mike McComish.
Replacements: Adrian Flavin, Conor Higgins, Mike McCarthy, Johnny O'Connor, Miah Nikora, Conor O'Loughlin, Aidan Wynne.
Guinness PRO12
Suite 208, Alexandra House,
The Sweepstakes
Ballsbridge, Dublin 4, Ireland
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