Cooper replaces young lock Dominic Day while Thomas comes in for Phil John at loose-head prop.
Both teams will be seeking their first win in the league after opening round defeats but Scarlets Director of Rugby Phil Davies is looking forward to the showdown.
"We had a couple of exciting games last year and hopefully this will be no different," he said. "We had a disastrous start to our game at the Liberty Stadium last season when we lost our fly-half before the game and the Ospreys put a lot of points on us early on. I'm sure it will be a great occasion."
Scarlets:
15 Morgan Stoddart
14 Garan Evans
13 Regan King
12 Gavin Evans
11 Matthew Watkins
10 Ceiron Thomas
9 Gavin Cattle;
1 Iestyn Thomas
2 James Hayter
3 Deacon Manu
4 Vernon Cooper
5 Adam Eustace
6 Dafydd Jones
7 James Bater (capt)
8 Nathan Thomas
Subs: Bruce Douglas, Ken Owens, Lou Reed, Jonathan Edwards, Liam Davies, Darren Daniel, Jonathan Davies
Guinness PRO12
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