One of the changes is in the backs with Ashley Smith replacing Gareth Maule in the centre after Maule failed to recover from a shoulder injury sustained against Ulster.
The other changes are among the forwards with Adam Black coming in for Hugh Gustafson, Michael Owen replaces Joe Bearman at No.8 and Colin Charvis will captain the side and comes in at blindside flanker for Dan Lydiate.
Dragons Team
15. Kevin Morgan
14. Gareth Wyatt
13. Rhodri Gomer Davies
12. Ashley Smith
11. Richard Mustoe
10. Ceri Sweeney
9. Wayne Evans
1. Adam Black
2. Steve Jones
3. Rhys Thomas
4. Luke Charteris
5. Andrew Hall
6. Colin Charvis (c)
7. Richard Parks
8. Michael Owen
Replacements
16. Hugh Gustafson
17. Ben Daly
18. Joe Bearman
19. Jamie Ringer
20. Aled Thomas
21. Martyn Thomas
22. Alex Walker
Guinness PRO12
Suite 208, Alexandra House,
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Ballsbridge, Dublin 4, Ireland