Horgan partners Christian Warner at centre while the other changes in the backline see Ireland 'A' cap Ross McCarron come in for his first start of the season at full-back.
Ireland internationals Rob Kearney and Luke Fitzgerald have been named on both wings with Cillian Willis again partnering Jonathan Sexton at half-back.
In the pack, Cameron Jowitt partners Devin Toner at second row with Shane Jennings forming a dynamic and exciting back-row alongside Stephen Keogh and Kevin McLaughlin.
Malcolm O'Kelly is named on a bench which includes fellow international Keith Gleeson, alongside Ireland 'A' stars Brian Blaney, Chris Keane and Fergus McFadden.
Interestingly, 12 of the squad to face Glasgow have come through the Academy system in recent years.
LEINSTER:
15: Ross McCarron
14: Luke Fitzgerald
13: Shane Horgan CAPTAIN
12: Christian Warner
11: Rob Kearney
10: Jonathan Sexton
9: Cillian Willis
1: Stan Wright
2: Bernard Jackman
3: Stephen Knoop
4: Cameron Jowitt
5: Devin Toner
6: Stephen Keogh
7: Shane Jennings
8: Kevin McLaughlin
REPLACEMENTS:
16: Brian Blaney
17: Cian Healy
18: Malcolm O'Kelly
19: Keith Gleeson
20: Chris Keane
21: Fergus McFadden
22: Fionn Carr
REFEREE:
Hugh Watkins (WRU), SUB REFEREE: Neil Paterson (SRU), TOUCH JUDGE: Peter Carruthers (SRU), TMO: Peter Allan (SRU)
Speaking ahead of Friday night's Magners League clash with the Glasgow Warriors, Leinster and Ireland hooker Bernard Jackman says that the squad are focused on getting back to winning ways at Firhill.
"The focus this week has been on getting back on track. Glasgow are a tough team and while they may not be a glamour side, we know how difficult opponents they can be. They already had a good squad before adding some of the Borders' players over the summer.
"Glasgow had a good run in the Challenge Cup and finished above Edinburgh in the Magners League last year, so we know that we will need to be at our best.
"Coming off a defeat like we suffered last week, you can't just block it out. You don't just forget about it. You have to be hard on yourself, as we were when analysing the game in the early part of the week. You can then see what you did or didn't do. It's now about concentrating on putting in a strong performance and making amends.
"As a squad we were disappointed and embarrassed about our performance last weekend. We let ourselves down for a half-hour period in the second half and we were punished for it.
"We need to be mentally and physically strong because Glasgow will test us. They can play a smart kicking game, are physical around the fringes, and they'll be more familiar with the ground which is different to what you'd typically experience.
"It's narrower than you'd expect - as it's a football ground - but in saying all that, the last time we played there we won (21-18) two years ago.
"The way we have to look at it is that we're not out of the competition. It's not a 'knock-out' situation and we have a chance to make amends this weekend. We need to develop a stronger culture of consistency. We have got to be at the level where we compete week in, week out.
"We got a monkey off our back by winning in Wales last time out, but it's important that we finish on a high before the gap in the calendar next weekend.
"Our away form let us down last year, so I don't think there's any fear of admitting that there should be a positive reaction by Leinster this weekend. There's no excuse for us not to come out with all guns blazing on Friday."
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