This might seem like a daunting task but Bowe has previous against the province, having scored a try against them for the Ospreys in the competition's first-ever play-off at the RDS back in 2010 - ruining then-coach Michael Cheika's final game in charge.
Last year Bowe was a spectator as Ospreys upstaged Leinster in the final at the same venue and the 29-year-old is hoping for more of the same this time around in Ulster colours.
"It's a difficult proposition; everybody knows that to beat Leinster anywhere is tough but to beat them in their own back yard is going to be extremely difficult," Bowe told the Belfast Telegraph.
"But Ulster have played some great rugby this year. We had a bit of a dip in the middle of the season, but we're back, feeling confident, playing some good rugby and looking dangerous.
"I don't think we could be in a better way going into this match."