The Lions have made five changes to their side including the introduction of Tommy Bowe to the right wing in place of Blues winger Alex Cuthbert, but Warburton is adamant there is no room for complacency as his side look to capture the series win.
"The potential achievement will be something that no-one has achieved for the last four tours," said Warburton, who appeared in 11 RaboDirect PRO12 games for the Blues this season.
"But that is something we are really looking forward to and I love that. The players are in the squad because they perform well in the biggest games.
"Normally, you are pretty nervous in the week going into a big game for your club or country, but the feeling ahead of this one is complete excitement, knowing what you could achieve.
"But we know we are going to have to do something special to make sure we do that. There is no complacency thinking there is another opportunity next week, because the momentum would completely swing.
"Australia would go into another home match to finish after winning a game, so we definitely want to finish it off this weekend, and the players are ready to do that."