Silverware and vital RaboDirect PRO12 points are the priority for the nation's top players who run out with the added incentive of promoting themselves into Scotland contention for the 2014 RBS 6 Nations.
Head coach Alan Solomons, said: "This is the oldest rugby derby in the world so we must take cognisance of that rich history and tradition. It's a privilege for all the staff and players to be involved in it.
"Most derbies are tight, hotly-contested affairs and I think that this one will be no different.
"There is a lot of emotion involved in these games, but it's a question of ensuring that the emotion is correctly channeled.
"The way to do that is by focussing on the elements on which you have got to deliver.
"When all is said and done, it's game of rugby, and one has got to deliver a good performance to get any form of outcome."
The introduction of loose-head prop Wicus Blaauw as a rotated replacement for Scotland internationalist Alasdair Dickinson is the only change to the side that muscled past Leinster at the same venue last weekend.
The match will be Blaauw's fourth start in 12 appearances this season, the most recent of which came in the club's away win over Gloucester in the Heineken Cup a fortnight ago.
The faith shown in the starting line-up means club stalwart Roddy Grant will lead the team out on his 100th appearance and that lock Ollie Atkins retains his starting role, despite the return of Izak van der Westhuizen, who starts on the bench.
Former Hawke's Bay captain and number 8 Mike Coman and on-loan stand-off Tony Fenner - both unused replacements against Leinster - are still in line to make their club debuts if called upon from the bench.
Edinburgh Rugby team to play Glasgow Warriors at Murrayfield Stadium on Boxing Day (26 December, kick-off 3.05pm) - live on BBC ALBA
15 Jack Cuthbert
14 Dougie Fife
13 Nick De Luca
12 Ben Atiga
11 Tom Brown
10 Greig Tonks
9 Greig Laidlaw CAPTAIN
1 Wicus Blaauw
2 Ross Ford
3 Willem Nel
4 Grant Gilchrist
5 Ollie Atkins
6 Cornell Du Preez
7 Roddy Grant
8 David Denton
Substitutes
16 Aleki Lutui
17 Alex Allan
18 Geoff Cross
19 Izak van der Westhuizen
20 Mike Coman
21 Grayson Hart
22 Tony Fenner
23 Sam Beard
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